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	Subjects     ESSENTIALS  ·  Allergy Symptoms  ·  Food Allergies/Intolerances  ·  Skin Conditions  ·  Allergist Locator  ·  Dermatologist Locator   BUYER'S GUIDE About Allergies Additives Alternatives Basics/FAQ Allergic to Cats? Children Allergies Chemical Reactions Corn Allergy Dark Circles Dust Mites Red, Itchy Eyes Seasonal Allergies Food Allergies Fragrances Gluten Intolerance Allergic Headaches Hives (Urticaria) House Cleaning Indoor Air Lactose Medications Milk Allergy Molds Peanut Allergy Allergic Pets Pollen Allergy Prayer Ragweed Allergy Recipes Skin Reactions Subject Library  All articles on this topic   Stay up-to-date! Subscribe to our newsletter. Advertising > Free Credit Report > Free Psychics		Are Your Medications Making You Sick? The Inactive Ingredients May Be the Cause    Join This Discussion "I have to avoid all corn, as much as possible. Unfortunately, cornstarch is in my allergy pills, and my thyroid meds, and there doesn't seem to be anything I can do about it. I have to take them." DONNIEJ     Related Resources • Corn Allergy • Sensitivity to Additives • What Is Hidden Lactose?    From Other Guides • About Dermatology    Elsewhere on the Web • Drug Additives Causing Side Effects • Guide to Pharmaceutical Excipients     The inactive ingredients in over-the-counter and prescription medications, as well as vitamins and supplements, could be troublesome for some allergic individuals. If symptoms still exist after avoiding known allergens, check any supplements or medications you are taking for inactive ingredients. You may be ingesting the troublesome food or ingredient without knowing it. Through an email correspondence, I discovered an Allergies Site visitor was taking 14 different medications and had a diet that was restricted in food such as no wheat, rye, ALL corn products, and no type of fish or pork. I suggested corn could be in some of the medications. Here is the response I received: "I just called Walgreen's and corn is in several of my medications. I'm picking up the breakdowns tomorrow when I pick up ANOTHER medication." Here is an individual that was told to restrict ALL corn products but was given medications that contained corn. Inactive ingredients are used for a variety of reasons -- as a binder to hold ingredients together; as a coating for increased stability, for appearance or to mask the taste or odor; as a diluent to liquify; as a filler to make solid; as an enhancer to increase the stability of the active ingredients; as a lubricant to make it flow well; and as a preservative to retard spoilage. While most individuals tolerate inactive ingredients without problems, keep in mind these ingredients are capable of inducing adverse effects. Allergic individuals should ask their pharmacists for all inactive ingredients or read the product labels carefully prior to taking any prescription or over-the-counter product. Ask the pharmacist if the medication contains anything that could cause an allergic reaction. To help avoid possible reactions, inform your pharmacist of any allergies or sensitivities you have. At times, the manufacturer may need to be contacted to determine all ingredients. Common Suspects BHA and BHT are used as fillers in vitamin and mineral supplements. Sulfites are used to maintain the stability and potency of certain medications. They are in many anti-asthma drugs, in some anti-inflammatories, antibiotics, and the anti-allergy drug epinephrine. Benzalkonium chloride is a preservative found in asthma inhalers and some nasal decongestants. Benzyl alcohol is used as a preservative in many injectable drugs and solutions. Corn may be used in aspirin, lozenges, oitments, suppositories, vitamins, laxatives and capsules. Most solid or liquid medications contain corn starch or corn syrup. Dyes and other coloring agents are used in almost every medication to improve appearance and to provide a unique product identity.The Food and Drug Adminstration (FDA) has approved over 100 dyes to be used in pharmaceutical preparations. One example is Tartrazine, also known as FD&C Yellow No. 5. Lactose, or milk sugar, is used as the base for more than 20 percent of prescription drugs and about 6 percent of over-the-counter medicines. Propylene glycol is an ingredient used to make drugs more soluble. Sweeteners such as aspartame and saccharine are used in many chewable tablets and liquid medications. Examples Here are a few allergy medications listed with their inactive ingredients: Actifed Cold & Allergy: Corn starch, flavor, hydroxypropyl methylcellulose, lactose, magnesium stearate, polyethylene glycol, potato starch, povidone, sucrose, and titanium dioxide. Allegra: Croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and pregelatinized starch. The aqueous tablet film coating is made from hydroxypropyl methylcellulose, iron oxide blends, polyethylene glycol, povidone, silicone dioxide, and titanium dioxide. Allegra-D: Microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, carnauba wax, stearic acid, silicon dioxide, hydroxy propyl methylcellulose and polyethylene glycol. Claritinex: Dibasic calcium phosphate dihydrate, microcystalline cellulose, corn starch, talc, carnauba wax, white wax, coating material consisting of lactose monohydrate, hydroxypropyl methylcellulose, titanium dioxide, polyethylene glycol, and FD& C Blue #2 Aluminum Lake. Claritin: Corn starch, lactose, and magnesium stearate. Sudafed Cold and Allergy: Lactose, Magnesium stearate, potato starch and povidone. Zyrtec: Corn starch, lactose, magnesium stearate, povidone, titanium dioxide, hydroxypropyl methylcellulose, and polyethylene glycol. How About You? 1)  Have you suffered reactions from the inactive ingredients in over-the-counter or prescription medications? 2)  Have you had to stop taking a medication because of the inactive ingredients? To participate in these polls, click on the underlined words from each question. Recent Discussions  Allergies   Join these forum conversations     Mayo Clinic   asthma   Allergy to Carbohydrates?   Tired, hot faced, itchy HELP   JUST FEELING ROTTEN  Start a chat now! Subscribe to the Allergies Newsletter Name Email Previous Features Email this page!

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Did You Know?

• In 1970"s Surgeon General requires WARNING LABELS on all cigarette products                 
• 20 years later the nation faces a health calamity that could cost trillions of dollars and millions of lives                                                                 
• Many of our personal care items have WARNING LABELS as well...that we don't know are there or we ignore them   
  
• When some of these ingredients interact with other substances they can increase the risk of cancer
  
• In 1938, when the FDA grandfathered these ingredients as safe, no studies were done on long term use of products with so called acceptable amounts of these ingredients

It is NOW known these ingredients do get into our bodies through their intended use 20 years from now, what will we have proven about these ingredients, their use and their effect on our health? Or will we still be asking the wrong questions?

Are there any clues today that might help?

We think so!

What you are about to read is shocking...Incredible, but true!

Before you dismiss this, go to your bathroom and check some labels. You'll find Sodium Lauryl Sulfate and Propylene Glycol (not to mention hundreds of other chemicals) in toothpaste, conditioners, cosmetics, shampoos, lotions and many other common products...you and your loved ones use several times, every day.

Could these ingredients possibly have any long term side effects?

• Why is the rate of cancer soaring?

• Why is the rate of heart disease soaring?

• Where did Alzheimer's come from?

• Why do so many people need glasses or contacts?

• Why are we the country leading the world in the proliferation of degenerative disease?

• Why are we spending a trillion dollars annually on Health Care for?

• Why are we not getting better?

There is something going on...and it's not pretty. When you know the facts about what these chemicals found in our everyday products are and where they come from and what they cause...you'll be shocked...and then you should get angry

DEFINITIONS

(SLS and SLES) - Harsh detergent implicated in contact dermatitis, hair loss, systemic retention, and possible damage to eye formation in young children. Avoid these ingredients.

Propylene Glycol

 A very common carrier in cosmetic products and baby products. Serious health concerns are being raised over the use of this chemical (Material Safety Data Sheet for Propylene Glycol clearly states to "Avoid skin contact".)

Natural Cosmetics

The term "natural" means virtually anything the manufacturer wishes it to mean. As whole, natural cosmetics are purely an advertising gimmick. (Beware of these terms).

What is Propylene Glycol?

In the industrial world propylene glycol is used in: 
* Antifreeze 
* Brake and Hydraulic Fluid 
* Airplane Deicer 
* Paint and Coatings 
* Floor Wax 
* Portable Water Systems 
* Swimming Pools 
* Liquid Laundry Detergents 
* Pet Food and Tobacco

Side effects of Propylene Glycol

This common ingredient is found in many beauty creams, cleansers and makeup. It is also found in children's personal care products. The American Academy of Dermatologists Inc. published a clinical review in January 1991, which showed propylene glycol to cause a significant number of reactions and was a primary irritant to the skin even in low levels of concentrations.

It has been shown that Propylene Glycol: 

• Has severe adverse effects and has been found to cause contact dermatitis, kidney damage and liver abnormalities
• Inhibits skin cell growth in human tests 
• Damages cell membranes causing rashes, dry skin and surface damage to the skin.

What is Sodium Lauryl Sulfate?

In the industrial world sodium lauryl sulfate is used as: 

• Garage Floor Cleaner
• Engine Degreasers 
• Car Wash Soaps

Side Effects of Sodium Lauryl Sulfate

The greatest concern of many scientists is centered around SLS, a detergent found in approximately 90% of commercial shampoos, including "no more tears" baby shampoos

A study done at the Medical College of Georgia has shown that: 
shampoos (with SLS) could retard healing and keeps children's eyes from developing properly, children under six are especially vulnerable to improper eye development (summary of Report of Research to Prevent Blindness, Inc. conference) 

• SLS can cause cataracts in adults and delays the healing of wounds in the surface of the cornea

• SLS build up in the heart, liver, lungs and brain and can cause major problems in these areas

• SLS causes skin to flake and to separate and causes substantial roughness on the skin

• SLS is such a caustic cleanser that it actually corrodes the hair follicle and impairs its ability to grow hair

• SLS is routinely used in clinical studies to deliberately irritate the skin so that the effects of other substances can be tested.

 
"Modern testing is proving time and time again that many ingredients used in personal care products are not good for the body, skin, or hair" .

Chemical Sensitivity and Allergies 
Today is commonly accepted that even low-level exposure to a number of different chemicals can cause a wide variety of chronic diseases, according to Nicholas Ashford, Ph.D., J.D., of the Massachusetts Institute of Technology and Claudia Miller, M.D., M.S.,M.A., of the University of Texas.

In addition, Michael A. Evans, Ph.D. Associate Professor at the University of Illinois College of Medicine, believes 70 to 80% of human cancer is due to synthetic chemicals that are not themselves completely carcinogenic, but become carcinogenic when they interact with other environmental or genetic factors.

Today, people are exposed to chemical concentrations far greater than were previous generations. Also, ecological changes in the environment are occurring grater than the human body's capacity to adapt to them. "It is interesting to observe how conventional medicine is beginning to acknowledge that food and chemicals in the environment can cause a broad spectrum of physical ailments". "Physicians who will continue to lead the way toward effective, physiologic therapy will be those who have spent years listening to their patients and exploring alternatives that offer the hope of helping them." It wont hurt to start looking into alternatives, your health is important to you. Here is your opportunity to try these products that are safe for all ages. "YES, these are the safest products, for you and your children.

NEWAYS is a member of the Cancer Prevention Coalition. Dr. Samuel Epstein, M.D., is author of the Politics of Cancer Revisited, The Breast Cancer Prevention Program, The Safe Shopper's Bible, founder of the Cancer Prevention Coalition and the 1998 "Alternative Nobel Prize" Winner. Dr Epstein endorses Neways' Personal Care Products. These products do not contain potentially cancer causing ingredients.

References:
Journal of the American College of Toxicology; Vol. 2, No. 7, 1983
By David L. Kern, New health and longevity
Dr. Keith Green, Ph.D, D.Sc., Medical College of Georgia
Higuchi, Araya and Higuchi, school of medicine, Tohoku Univeristy; Sendai 980 Japan
FDA Report 1978

3-YEAR-OLD NEW YORK CHILD
POISONED TO DEATH IN DENTAL CHAIR

 June 28, 1974: Little William Kennerly, age 3, of New York died just four hours after receiving a brush-on stannous fluoride treatment during his first and only trip to the dentist. William didn't know that he wasn't supposed to swallow the fluoride, and he paid with his life.

Extracts from the autopsy report, performed by a Dr. Tomo on May 25, 1974 at Kings County Mortuary:

"William Kennerly"
Case #K74-3511   AUTOPSY REPORT

Age: 3 years 
Height: 39" 
Weight: 32 lb

Clinical history - the child swallowed about 45cc of 2% stannous fluoride solution in the pediatric dental clinic, Bristol Street Clinic, at 9:30 a.m. He was given Epinephrine I.M. in dental clinic and sent to Brookdale Medical Center for close observation. The child came to Brookdale Medical Center at 12:30 noon, was well until 1:00 when suddenly went into cardiac respiratory arrest and was in shock. The child vomited out and had an unrecordable blood pressure. He finally expired on May 24, 1974, at 2:00 p.m.

A toxicologist's report stated that little William had swallowed the equivalent of three lethal doses. His parents later collected several hundred thousand dollars in a wrongful-death lawsuit, but that was small consolation for the senseless loss of their son.

Toothpaste is similar in this regard, because a typical family size 7 ounce tube of toothpaste contains enough stannous fluoride or sodium fluoride to kill a 20-pound child. To test this, just call the 800 number listed on your toothpaste box, tell them that your 2-year-old child has just eaten half a tube of toothpaste and that he's now vomiting. Act frantic, and watch how quickly your call gets patched directly to a Poison Control Center. (It's common for a child to vomit for 12 hours, after eating a large quantity of toothpaste.)

SOLUTION? Neways products do not contain any fluoride or any other harmful ingredients that would affect your health in any way. INVEST IN YOUR HEALTH using "state of the art products."

Ask about wholesale pricing!
Distributorships available in your area
Call this number now!  800-326-3051

Independent Neways Distributor
Mabel Campuzano
Rochester, NY
Phone & Fax 585-621-2655 
Info@healthytomorrow.com

All products and ninety percent of the information in this Website are property of Neways International. This Website is written and maintain by Independent Neways Distributor Mabel Campuzano. Portion of this Website cannot be reproduced without a written consent.

Copyright @ Mabel's Gold-Mine of Health  1998 - 2001

06/16/02

DEFINITIONS

Sodium Lauryl Sulfate and Sodium Laureth Sulfate
(SLS and SLES) Harsh detergent implicated in contact dermatitis, hair loss, systemic retention, and possible damage to eye formation in young children. AVOID THESE INGREDIENTS.

Propylene Glycol
A very common carrier in cosmetic products and baby products. Serious health concerns are being raised over the use of this chemical. (Material Safety Data Sheet for Propylene Glycol clearly states to "AVOID SKIN CONTACT".)

Natural Cosmetics
The term "natural" means virtually anything the manufacturer wishes it to mean. As whole, natural cosmetics are purely an advertising gimmick. (Beware of this term.)

Taken from MORE DANGEROUS BEAUTY: Potentially Harmful Ingredients in Cosmetics by David L Kern (Editor of New Health and Longevity)

WHAT IS PROPYLENE GLYCOL?  In the industrial world propylene glycol is used in:

• Antifreeze
• Brake and Hydraulic Fluid
• Airplane Deicer
• Paint and Coatings
• Floor Wax
• Portable Water Systems
• Swimming Pools
• Liquid Laundry Detergents
• Pet Food and Tobacco

WHAT IS LAURYL SULFATE?  In the industrial world sodium laurel sulfate is used as:

• Garage Floor Cleaner
• Engine Degreasers
• Car Wash Soaps

SIDE EFFECTS OF PROPYLENE GLYCOL AND SODIUM LAURYL SULFATE
(The effects of these chemicals are clearly more than skin deep.)

PROPYLENE GLYCOL

This common ingredient is found in many beauty creams, cleansers and makeup.  It is also found in children's personal care products. The American Academy of Dermatologists Inc. published a clinical review in January 1991 which showed propylene glycol to cause a significant number of reactions and was a primary irritant to the skin even in low levels of concentrations.

It has been shown that propylene glycol:

• has severe adverse health effects and has been found to cause contact dermatitis, kidney damage and liver abnormalitites
• inhibits skin cell growth in human tests
• damages cell membranes causing rashes, dry skin and surface damage to the skin

SODIUM LAURYL SULFATE

The greatest concern of many scientists is centered around SLS, a detergent found in approximately 90% of commercial shampoos, including "no more tears" baby shampoos.

A study has shown that:

• shampoos (with SLS) could retard healing and keeps children's eyes from developing properly, children under six are especially vulnerable to improper eye development (Summary of Report of Research to Prevent Blindness, Inc. Conference.)
• SLS can cause cataracts in adults and delays the healing of wounds in the surface of the cornea
• SLS builds up in the heart, liver, lungs and brain and can cause major problems in these areas
• SLS causes skin to flake and to separate and causes substantial roughness on the skin
• SLS causes dysfunction of the biological systems of the skin
• SLS is such a caustic cleanser that it actually corrodes the hair follicle and impairs its ability to grow hair
• SLS is routinely used in clinical studies to deliberately irritate the skin so that the effects of other substances can be tested

Modern testing is proving time and time again that many ingredients used in personal care products are not good for the body, skin, or hair.

PersonalMD Services   Family Health   Women's Health   Children's Health   Men's Health   Senior's Health       Health Centers   Alternative Medicine   Cardiac Care Center   Cancer Center   Emergency Dept   Medical Advances   Nutrition Central   Pulmonary Center   Sports Medicine   Travel Medicine       Resources   Drug Interaction   Drugs & Medications   Health Encyclopedia	Drug Additives Causing Side Effects NEW YORK, Feb 10 (Reuters) -- 'Inactive' fillers, dyes, and flavorings in common drugs may be causing adverse reactions, and should be clearly marked on ingredient lists, experts say. "The voluntary system (for ingredient disclosure) is clearly inadequate," says a new report from the American Academy of Pediatrics (AAP). "Again, the AAP recommends mandatory labeling for all prescription and over-the-counter drugs." Additives -- often used as fillers, sweeteners, and dyes -- "frequently make up the majority of the mass or volume of oral and (non-oral) drug products," according to the AAP. There are over 773 such additives already approved for use in medications by the Food and Drug Administration (FDA). Researchers say most are "considered to be inert and do not add to or affect the intended action" of the drug itself. But the AAP had real concerns about eight major drug additives: -- Sulfites, antioxidants found in many anti-asthma drugs, have been known to induce "serious reactions" such as wheezing, breathing difficulties and chest tightening in asthmatic children. Sulfites are also found in some anti-inflammatories, antibiotics, and the anti-allergy drug epinephrine. -- Benzalkonium chloride, a preservative found in asthma inhalers and some nasal decongestants, can, itself, induce constriction of the bronchial airways in a small percentage of asthmatics. Although AAP experts say "a single dose is unlikely to cause a reaction," they recommend that the compound not be included in drugs used to treat those with severely compromised lung function. -- Sweeteners such as aspartame (commonly found in diet soft drinks), and saccharine are also used as drug additives, especially in those aimed at children. Headaches are the most common side effect of aspartame, researchers say, adding that "up to 11% of patients with chronic migraine headaches reported headaches triggered by aspartame." The sweetener has also been linked to hallucinations, panic attacks, dizziness, and mood swings in rare cases. Saccharin is not recommend for children with "sulfa" allergies, and has been linked to short-term problems with infant muscle tone, 'lazy' eye, irritability, and insomnia. -- Benzyl alcohol, another preservative, has been linked to "a number of neonatal deaths and severe respiratory and metabolic complications in low-birth-weight premature infants." Most drugs have very low levels of benzyl alcohol and are not suspected of causing infant complications, although the AAP note that "the effects of lower amounts... have not been adequately studied." -- Dyes are used in almost every medication, with varying effects. For example, the yellow dye tartrazine is harmful in a minority (2.4%) of those already allergic to aspirin. Another dye, 'sunset yellow' has been associated with gastric upset. The suspected carcinogenic effects of the dye erythrosine has sparked its removal from all topical products and most oral drugs. -- Lactose, or milk sugar, is known to affect lactose-intolerant individuals, causing diarrhea, dehydration, and cramping. It's often used as a filler in capsules and tablets. -- Propylene glycol, an ingredient used to make drugs more soluble, can bring on respiratory problems, irregular heartbeat, low blood pressure, and seizures in rare cases. Skin rashes have occurred in 4.5% of 487 patients in one study on detecting sensitivity to propylene glycol. The AAP point out the "increasing number of reports of adverse reactions" associated with drug additives, and say they stand by an earlier statement urging "the FDA mandate labeling of over-the-counter and prescription formulations to include a... list of inactive ingredients." SOURCE: Pediatrics (1997;99(2):268-278) DISCUSSION See what PersonalMD members have to say about this article.   News Headlines New Cancer Drug Shrinks Tumors, Doesn't Extend Life No Extra Disease Seen in Chemical-Exposed Gulf War Veterans Exhaustion's Effect on Blood Increases Heart Attack Risk Sugared Soft Drinks Make You Softer in Middle Women's Brains Better at Handling Anger Prostate Surgery Helpful But No Key To Longevity   Feature Stories Run for Your Life? No, Calmly Assess the Risk Experts Offer Practical Advice for Scary Times Blood Transfusions Raise Death Risk in Very Ill Study: Children Exposed to Chemical Found on Bacteria Have Fewer Allergies Weight-loss Deception Found Ads for Many of Those Pills, Patches, Creams and Wraps Are Grossly Exaggerated, FTC Says Age of Mom Not Risky for Twins, Triplets Our Life Spans Are Expanding with Our Waistlines
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Propylene Glycol Propylene Glycol is a colorless, viscous, hydroscopic liquid CH3, CHOHCH2OH, used in anti-freeze solutions, in hydraulic fluids, and as a solvent. Also called “propanediol”. - American Heritage Encyclopedia Dictionary. Propylene Gycol is used in: ANTI-FREZE* BRAKE* AND HYDRAULIC FLUID* PAINTS AND COATINGS* FLOOR WAX* LAUNDRY DETERGENTS* PET FOOD* TOBACCO* COSMETICS* TOOTHPASTES* SHAMPOOS* DEODORANTS* LOTIONS* PROCESSED FOODS and many more personal care items. Propylene Glycol also serves as a Humectant - a substance that helps retain moisture content, or simply- it prevents things from dying out. That’s why some pet foods are soft and chewy. This, of course, is a good reason it’s in cosmetics and personal care items. It makes the skin to feel moist and soft. And, the products don’t dry out. Propylene Glycol is also found in baby wipes and even some processed foods! Go ahead, check your labels! How Much of this STUFF is OK? PROPYLENE GLYCOL: Implicated in contact dermatitis, kidney damage and liver abnormalities; can inhabit skin cell growth in human tests and can damage cell membranes causing rashes, dry skin and surface damage. -- Material Safety Data Sheets(MSDS) A published clinical review showed propylene glycol causes a significant number of reactions and was primary irritant to the skin even in low levels of concentrations. - The American Academy of Dermatologists, inc.; Jan. ‘91 ACUTE EFFECTS: May be harmful by inhalation, ingestion or skin absorption. May cause eye irritation, skin irritation. Exposure can cause gastro-intestenal disturbances, nausea, headache and vomiting, central nervous system depression. -- Material Safety Data Sheets(MSDS)                    What can PROPYLENE GLYCOL Do To Us? In 1938, the FDA grand fathered the use of several ingredients as safe for personal care items, with restrictions of course. Based on what? Like DEA, PROPYLENE GLYCOL may be absorbed through the skin. Do You Really Need To Wait For A Study? Has anyone or any company tested the long range side effects from constant use of these products? We haven’t found any. Do these complex chemicals build up in our bodies? If Propylene Glycol keeps things from dying out- how? If it’s absorbed into our bloodstream and into our cells, what does it do? Does it affect any of the simple, natural biological functions at the cellular level? You don’t need a study to say - it’s possible, even likely. You do need a conclusive study to make the producers stop using these ingredients! Yes, this is the beginning to sound like another great American Tobacco Scandal. But before you get complacent and think the government is going to step in - think again. Look how long it has taken the cigarette pushers to get grilled ……..20 Years after the first Surgeon General’s report. In fairness, the producers of these products are just doing business as usual. They use Propylene Glycol and other questionable substances because it’s the way things have been done for decades and the FDA isn’t stopping them. These common, plentiful ingredients are inexpensive and consumers generally shop price. Changing to safer ingredients would mean slightly higher costs in a very competitive market. Now that DEA has been linked to cancer, the FDA has something new to valuate, while the producers have a new issue to defend. If DEA is banned or restricted, how long will it take? At this time it’s known if Propylene Glycol is the target of many studies. The folks formulating products with propylene glycol probably won’t be changing anything soon. So, if you think Anti-Freeze ingredients in your expensive cosmetics and personal care items is disgusting...and this is just the tip of the iceburg! Go back ¨ Next page

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         publikationen

COMPARISON OF ETOMIDATE IN PROPYLENE GLYCOL AND A LIPID EMULSION FORM IN HEALTHY CANINE PATIENTS.

M Mosing, U Auer, M Teinfalt. Anesthesia Team, Central Laboratory, Veterinary University of Vienna, Veterinärplatz 1, A-1210

Etomidate has been shown to be an anesthetic agent with little effect on vital parameters during and after induction. The major side effects are excitement, myoclonus, vomiting, salivation, defecation and apnea. Etomidate is known to suppress adrenocortical function and cause hemolysis due to the propylene glycol form. The aim of this study was to determine the anesthetic and hemodynamic effects and the prevalent side effects, the duration of cortisol suppression and the hemolytic effect of the two different forms in healthy dogs.

The dogs were sedated with 10 mg/kg of medetomidine and 0,02 mg/kg atropin intramuscularly. Fifteen minutes later all of them received 0,5 mg/kg of etomidat, half of them with the propylene glycol form, and the other half with the lipid emulsion form. Measurement of vital parameter begun 3 minutes before and stopped 10 minutes after the application of etomidate. Blood samples were taken before and, 1, 2, 3, 6, and 24 hours after the etomidate application.

The only major side effects observed was an apneic phase in 50 % of all dogs in both groups. All of them were intubated one minute after application was completed. The hemodynamic changes were not significant. The plasmacortisol levels were significantly reduced in both groups. The only difference between the groups was significant hemolysis in the propylene glycol group, without any sign of hemolysis in the lipid emulsion group.

We conclude, that the new form has the same pharmacodynamic effects as the propylene glycol form. The advantage is, that the lipid emulsion doesn´t cause hemolysis, so this form of etomidate can also be used as an infusion for maintainace.

1. Muir WW, Mason DE (1989). JAVMA, 194, 10, 1430-1436

2. Kruse-Elliott K et al (1987). Am J Vet Res, 48, 7, 1098-1100

3. Moon PF (1994) Lab Anim Scien, 44, 6, 590-594